acta satech Journal of the Life & Physical Sciences Babcock

Cytological Effects of Chloroquine on Root Mitosis of Allium cepa (L.)
*1Nwangburuka C. C. & 2+Oyelana O. A.
1Department of Agriculture, 2Department of Basic and Applied Sciences, Babcock University, Ilishan-Remo, PMB, 21244, Ikeja, Lagos, Nigeria. +Present address: Department of Biological Sciences, Redeemers University of Nigeria.
Accepted: September 8, 2011

ABSTRACT
The effects of chloroquine (antimalarial drug) on the mitosis of Allium cepa L. was investigated with a view to ascertaining its mutagenic effects. Onion roots were treated with 20%, 50% and 100% concentrations of chloroquine at 6hours, 12hours and 18hours duration respectively and distilled water as control. There was a significant difference (0.05%) among the mitotic indices (2.0, 2.06 and 0.7) for 20%, 50% and 100% concentrations of chloroquine respectively compared with the control (3.8). The result further showed that chloroquine induced cell mitotic abnormalities like anaphase bridge, fault polarization of anaphase, chromosome fragmentation, disorderly anaphase, C-metaphase and clumping of chromosomes at 20%, 50% and 100% concentrations and different time of exposure. The result implicated chloroquine as a mitotic depressor and confirmed chloroquine as mutagenic to plant cell, when absorbed in high dosage.
Download Article