acta satech Journal of the Life & Physical Sciences Babcock

Experimental culture of Ascaris species and histopathological effects on visceral organs of rats (Rattus) and mice (Microtus)
1 Akinboye, D. O., J. U. Ovansa 2, O. M. Agbolade 3, O. Fawole8, O. O. Akinboye 4, A. M. Amosu 1, N. O. S. Atulomah 1, S. N. Rebecca 5, E. Okwong 6 & B. M. Owodunni 7
1Department of Public and Allied Health, Babcock University, Ilisan-Remo, Ogun State. 2Ovansa J. U., Biology Department, Federal College of Education, Okene, Ogun State. 3Department of Plant Science and Applied Zoology, Olabisi Onabanjo University, PMB 2002, Ago-Iwoye; 4Department of Planning, Research and Statistics, Ministry of Health, Oyo State.5Department of Biological Sciences, Federal University of Technology, Yola. 6Department of Medical Microbiology/Parasitology, Faculty of Allied Health Sciences, University of Calabar; 7Department of Zoology, University of Ibadan, Ibadan, Oyo State. 8Department of Epidemiology, Medical Statistics and Environmental Health, College of Medicine, University of Ibadan, Ibadan, Oyo state.
2009

ABSTRACT
Ascaris lumbricoides is a cosmopolitan, gastrointestinal, parasitic nematode of man. Ascaris suum, infects pig and is similar to Ascaris lumbricoides. Studies of A. suum provides vital information about the biology of other zoonotic, ascarid nematodes. Eggs of A. suum were obtained from gravid females and incubated at 24oC to obtain infective stage which was administered to rats, (Rattus species) and mice (Microtus species) and their organs later examined. Lung tissues of rats showed severe haemorrhage and mild hyperplasia of peribrochiolar lymphoid tissues. Heart tissues of rats and mice showed cellular infiltration, with infiltrating cells which included lymphocytes. The heart tissues of rats, in addition to cellular infiltration, showed mild centrilobular fatty (vacuolar) degeneration of hepatocytes. No liver tissues of rats showed significant lesion. Intestinal tissues of rats showed cellular infiltration and hyperplasia at 42 days post-infection, lungs tissues of rats and mice showed cellular infiltration. There were cellular casts with mucous materials in the lumens of the intestines of rats and mice. The pathology associated with ascariasis is mainly due to the histological changes in the hostsí visceral tissues. These changes are believed to be caused by the immunological responses elicited by the host. These are usually allergenic, leading to disease syndromes.
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