Volume Volume V 13 / Issue 2 - September 2021

Evaluation of anti-inflammatory activity of 2,3-dimethylnaphthalene in carrageenan and cotton pellets-induced inflammation models

Olajide, L. O. and *Anyasor, G. N.

Department of Biochemistry, School of Basic Medical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ilisan Remo, Ogun State

September, 2021

ABSTRACT

Some naphthalene derivatives possess anti-inflammatory activity. This study evaluated the effects of different doses of 2,3-dimethyl naphthalene on two inflammatory models. Thirty male albino rats were assigned into six groups of five rats each. Group I: normal, group II: untreated control, group III: treated with 10 mg/kg b.w diclofenac, groups IV-VI treated with 5, 10, and 15 mg/kg b.w. 2,3-dimethyl naphthalene, respectively. Carrageenan-induced paw edema and cotton pellets-induced granuloma were used to evaluate the anti-inflammatory activity of 2,3-dimethyl naphthalene. GraphPad Prism® was used to analyze data. Data were expressed as mean ± standard error of the mean at a significance level of p < 0.05. The study revealed that 5, 10, and 15 mg/kg b.w. 2,3-dimethyl naphthalene suppressed paw edema by 55.82%, 21.49%, and 14.38% respectively, while 10 mg/kg b.w. diclofenac sodium suppressed paw edema by 81.50%. Furthermore, 5, 10 and 15 mg/kg b.w 2,3-dimethyl naphthalene significantly (p < 0.05) inhibited cotton pellets-induced granuloma by 11.48%, 38.52% and 39.69%, respectively, while 10 mg/kg b.w. diclofenac sodium inhibited cotton pellets-induced granuloma by 59.28%. Thus findings from this study showed that 2,3-dimethyl naphthalene could exhibit anti-inflammatory actions and its mechanism might be through interference with phase 2 of inflammatory stressors.